Leukostasis is rapidly progressive and fatal in the majority of patients 2,3. Hyperviscosity syndrome is a condition in which blood is unable to flow freely through the arteries. In general, symptoms of leukostasis are more common in leukemias with large, poorly deformable blasts, such as acute myeloid leukemia. The presence of pulmonary leukostasis has been associated with a lower survival rate. Pdf how i treat hyperleukocytosis in acute myeloid leukemia. The clinical, ra diologic, pathophysiologic, and therapeutic aspects of. How i treat hyperleukocytosis in acute myeloid leukemia. Rasburicase prevents tumor lysis syndrome despite extreme hyperleukocytosis article in pediatric nephrology 198. Autopsy confirmed the presence of the leukostasis syndrome.
Leukostasis is defined as clinical symptoms and signs in the presence of an absolute. How i treat how i treat hyperleukocytosis in acute myeloid. By continuing to browse this site you are agreeing to our use of cookies. Leukostasis syndrome pdf blood count itself, but complications such as leukostasis, tumor lysis syndrome tls and disseminated intravascular coagulation dic put the. Leukapheresis is indicated in the initial management of leukostasis. Therapeutic apheresis in hyperleukocytosis and hyperviscosity. The organs primarily affected are the central nervous system and lung.
Leukostasis is a complication of acute myeloid leukemia. This condition is most common in infants and children and can affect their growth by reducing. Rasburicase prevents tumor lysis syndrome despite extreme. Pdf hyperleukocytosis is commonly defined as a white blood cell wbc count exceeding. It is associated with hyperleukocytosis and a poor prognosis. Hyperleukocytosis and leukostasis in hematologic malignancies. Leukostasis in adult acute hyperleukocytic leukemia wiley online. Symptomatic hyperleukocytosis leukostasis is defined by a tremendously high blast cell count along with symptoms of decreased tissue perfusion.